A novel three-filament model of force generation in eccentric contraction of skeletal muscles.

A novel three-filament model of force generation in eccentric contraction of skeletal muscles.

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We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin Siemens GS36NVI3PG Free Standing 242 Litres A++ Upright Freezer Stainless Steel interaction upon active force production.In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions Tatami Cushion of cross-bridge models for isometric contractions.However, in contrast to cross-bridge models, the three filament model accurately predicts history-dependent force generation in half sarcomeres for eccentric and concentric contractions, and predicts the activation-dependent forces for stretches beyond actin-myosin filament overlap.